A urinary tract infection, or UTI, is an infection involving any part of the urinary system. Infections are typically limited to the urethra and bladder, but can also spread to the ureters and kidneys. UTIs are some of the most common and problematic of hospital-acquired infections as they are often associated with catheters or stents. Our model of an ascending urinary tract infection is used to determine the efficacy of novel antimicrobial agents and to guide dosing strategies in human patients.

Procedure
We have established a urinary tract infection model in mice in which animals are challenged with an infectious agent via intraurethral injection. Test article may be administered via oral gavage (PO) or intraurethral, subcutaneous (SC), intraperitoneal (IP), or intravenous (IV) injection. Each study parameter (animal strain, pathogen, comparator(s), and dosing schedule) can be customized to meet client needs.

The endpoint for this study is CFU burden in harvested organs and/or blood. Pharmacokinetic profiling, blood chemistry, additional tissue harvests, and histology are available upon request.

Sample Data

Pathogens
TransPharm has validated a urinary tract infection model using the following pathogens:

• Escherichia coli
  • CFT073
  • ATCC 700928
• Pseudomonas aeruginosa
  • ATCC 27853
  • ATCC 15692
• Klebsiella pneumoniae
  • ATCC BAA-2146

Additional validations available upon request.