Neisseria gonorrhoeae, the bacteria responsible for the sexually transmitted infection (STI) known as gonorrhea, infect more than 500,000 people in the United States each year. In fact, the Centers for Disease Control and Prevention (CDC) lists multi-drug resistant (MDR) gonorrhea as one of the top 5 most dangerous and urgent threats to public health. However, researchers have demonstrated that just one oral dose of a new antibiotic effectively treats mice infected with a virulent MDR strain of gonorrhea called WHO-X.
While antibiotic treatment is a well-known cause of antibiotic-resistant bacterial strains, new research shows that selection pressures occurring far before the widespread use of antibiotics have also been a contributing factor. Scientists from Norway and the UK used recently developed technology to create an evolutionary timeline of Enteroccocus faecalis, a common source of antibiotic-resistant septic infections in hospitalized patients around the world.
According to scientists at the National Institute of Environmental Health Sciences, a newly identified protein found in mosquitoes may also be effective at fighting viral infections in humans.
Antibiotic tolerance occurs when bacteria are able to survive in the presence of antibiotics. This is dangerous because tolerant bacteria can cause infections that persist even after treatment. Some bacteria are tolerant to beta lactam antibiotics such as penicillin. Drugs in this class kill bacteria by breaking down their cell walls. Until now, how tolerant bacteria survive this process was poorly understood.
Attine ants are a group of several ant species known as farmers because they grow their own food. Each member of the colony has a job on the farm. Harvester ants cut grasses and leaves and foragers carry the harvested vegetation back to the nest. There, worker ants...
S. pneumoniae initially colonizes the nose and throat, but from there it can spread to the bloodstream and other organs. Researchers at three universities worked together to understand how S. pneumoniae adapts to different sites in the body. Using three different bacterial strains, they measured bacterial gene expression at five locations in an experimental mouse model – the nasopharynx, lungs, blood, heart, and kidneys.
The United States has one of the safest drinking water supplies in the world thanks to improvements in infrastructure and water treatment methods over the last century. However, millions of Americans still get sick from waterborne illnesses every year. For the first time, researchers at the Centers for Disease Control (CDC) have generated an estimate of our country’s overall burden from waterborne disease.
Patients with asymptomatic C. difficile colonization are gaining attention as a potential source of transmission. Scientists at the Cleveland Clinic recently conducted a systematic review and meta-analysis of 19 studies published between 1975 and 2020 in order to evaluate the risk factors for asymptomatic C. difficile colonization among adults.
One of many barriers to the discovery of novel antibiotics is a lack of information sharing. Although antibiotic research has been underway since the discovery of penicillin in 1928, it is difficult for scientists to build on past work and avoid repeating the same...
A recent study out of New York has demonstrated an association among ventilator use, acute care hospital admission, and colonization with Candida auris. Colonization increases the risk for severe infection and the likelihood of transmission to other patients.