Gastrointestinal (GI) tract infections involve both the stomach and the small intestine. A number of pathogens cause uncomplicated and/or secretory diarrhea, and severe cases can lead to dehydration, sepsis, and even death. Some infections result from broad-spectrum antibiotic therapy, which can disrupt the gut microbiota and provide the opportunity for disease. The objective of our murine gastrointestinal colonization and infection model is to evaluate the efficacy of novel antimicrobial therapies for GI disease.
We have established a gastrointestinal infection model in mice in which animals are challenged with a pathogen via oral gavage (PO). Animals may be exposed to a cocktail of antibiotics in the drinking water to disrupt the intestinal microbiota and increase susceptibility to infection. Test article may be administered via oral (PO) or perirectal (PR) administration, subcutaneous (SC), intravenous (IV) or intraperitoneal (IP) injection, or via diet or drinking water. Each study parameter (animal strain, pathogen, comparator(s), dosing schedule) can be customized to meet client needs.
Endpoints for this study include mortality tracking, clinical observations, weight tracking, and CFU burden in feces, organs, and/or blood. Pharmacokinetic profiling, blood chemistry, tissue harvests, and histology are available upon request.Cases were only noted retrospectively in studies and reports, with no confirmed relation to the drug. Purchase Protopic Ointment Topgraf cheap no prescription They need to know if you have any of these conditions:-cold sores or shingles-decreased immune function-Netherton's syndrome-receiving any form of light therapy (phototherapy, UVA, or UVB) to your skin-skin infection-an unusual or allergic reaction to tacrolimus, other medicines, foods, dyes, or preservatives-pregnant or trying to get pregnant-breast-feeding This medicine is for external use only.
TransPharm has validated a gastrointestinal model using the following pathogens:
- Escherichia coli
- ATCC 48395
- Clostridium difficile
- ATCC 3255
- Enterococcus faecalis
- ATCC 700221
- ATCC 700802
- Enterococcus faecium
- Salmonella enterica serovar Typhimurium
- CDC 6516-60
Additional validations are available upon request.