Systemic Infection – Bacteremia
Bacteremia is defined as the presence of bacteria in the bloodstream, which is normally a sterile environment. As these bacteria multiply, a potentially life-threatening infection called sepsis can develop. These conditions arise from bacteria originating elsewhere in the body, including the lungs, abdomen, and urinary tract. Our bacteremia studies allow for in vivo screening of antimicrobial activity to rapidly identify the most promising therapies.
We have established a bacteremia model in mice (validation in rats is available upon request) in which animals receive a single challenge with an infectious agent via intravenous (IV) injection in the lateral tail vein. Animals may be administered test article via oral gavage (PO) or subcutaneous (SC), intravenous (IV), or intraperitoneal (IP) injection. The route, duration, and frequency of dosing can be customized to meet client needs. Endpoints for this study include mortality tracking and CFU load in harvested organs and/or blood. Pharmacokinetic profiling, blood chemistry, and histology are available upon request.
TransPharm has validated a bacteremia model using the following pathogens:
- Pseudomonas aeruginosa
- ATCC 13073
- Staphylococcus aureus
- ATCC 25904
- Streptococcus pneumoniae
- ATCC 700674
- Streptococcus pyogenes
Additional validations are available upon request.