NDM-1 and Drug Resistance

NDM-1 and Drug Resistance

NDM-1 is a gene that codes for New Delhi metallo-beta-lactamase 1, an enzyme that provides resistance to multiple classes of antibiotics, including carbapenems, cephalosporins, and penicillins. Pathogens carrying this gene typically carry other resistance genes as well, classifying them as superbugs because the infections are extremely hard to treat with commonly used antibiotics. NDM-1 isolates were first reported in India in 2008, likely due to overuse of antibiotics, crowded living conditions, and poor sanitation, but have since spread across the globe as a result of medical tourism and international travel. Further, NDM-1- containing genetic elements, such as plasmids, can quickly and easily be transferred between bacterial species. NDM-1 has been identified in several genera of Gram-negative bacteria, including Klebsiella, Escherichia, Enterobacter, and Acinetobacter.

TransPharm has validated peritonitis and soft-tissue infection models in mice using two bacterial strains containing the NDM-1 gene: Klebsiella pneumoniae (ATCC BAA-2146) and Escherichia coli (ATCC BAA-2469). We currently have data using meropenem and colistin as comparator drugs. Validations with additional bacterial strains and/or treatments are available upon request. Contact us today to learn more about our preclinical studies of NDM-1 bacteria or to request a free, no-obligation quote.

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