Peritonitis

Peritonitis is the inflammation of the peritoneum, the transparent membrane lining the abdominal cavity and covering the abdominal organs. Peritonitis can result from any perforation of the abdomen or as a complication of other medical conditions. Left untreated, it can lead to a severe, life-threatening infection throughout the body. Our peritonitis model allows for in vivo efficacy screening of antimicrobials to rapidly identify the most promising therapies.

Procedure
We have established a peritonitis model in both mice and rats in which animals are challenged with a pathogen via intraperitoneal (IP) injection. Gastric mucin is often used to establish the infection. Animals may be administered test article via oral gavage (PO) or subcutaneous (SC), intravenous (IV), or intraperitoneal (IP) injection. Each study parameter (animal strain, pathogen, comparator(s), and dosing schedule) can be customized to meet client needs.

Endpoints for this study include mortality tracking and CFU burden in harvested organs and/or blood. Pharmacokinetic profiling, blood chemistry, tissue harvests, and histology are available upon request.

Sample Data

Pathogens

- - Acinetobacter baumannii
    - ATCC 17961
  - Candida albicans
    - ATCC SC5314
  - Coxsackievirus B3
    - ATCC VR-30
  - Enterococcus faecalis
    - 03A1065
    - ATCC 700221
    - ATCC 700802
  - Enterococcus faecium
    - 03B1022
  - Escherichia coli
    - Vogel
    - ATCC 25404
    - ATCC BAA-2469
  - Klebsiella pneumoniae
    - ATCC BAA-2146
  - Mannheimia haemolytica
    - Strain 46571
  - Neiserria meningitidis
    - ATCC BAA-335
  - Pseudomonas aeruginosa
    - ATCC 15692
    - ATCC 27853
    - ATCC 33347
  - Staphylococcus aureus
    - ATCC 13709
    - ATCC 33592
    - ATCC BAA-1707 (USA400)
    - UC-76-rp
    - USA300
    - 01A1095
  - Staphylococcus epidermidis
    - ATCC 9491

Additional validations are available upon request.

Peritonitis

Peritonitis

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