TransPharm Preclinical Solutions offers an extensive range of validated models for efficacy testing of antibiotics, antivirals, antifungals, antiparasitics, as well as newer therapies using antibodies.

Preclinical Drug Efficacy Screening Studies

Acute infection models are used to screen compounds for antimicrobial activity in rodents and rapidly identify the most promising compounds. We can adapt current models or develop new models to meet your needs. Check out this blog post for more details on how we run our preclinical studies.

○ Abscess model
○ Bio-film model
○ Chagas disease model
○ Dermal models
• Deep wound
• Intradermal
• Scratch
• Tape stripping
○ Gastrointestinal model
○ Intracranial model
○ Intravaginal model
○ Otitis media model
○ Peritonitis model
○ Pulmonary model
○ Soft tissue model
○ Systemic models
• Bacteremia
• Fungemia
○ Urinary tract infection (UTI) model

Advanced Preclinical Studies

These studies involve highly specialized techniques and can be used in multiple therapy areas.

○ Cecal Ligation and Puncture (CLP) model
○ Cecal Ligation and Osmotic Pump (CLOP) model
○ Colon Ascendens Stent Peritonitis (CASP) model
○ Osteomyelitis model

Pharmacokinetic (PK)/Pharmacodynamic (PD) Studies

○ Exposure-Response Studies
○ Infected and non-infected blood/tissue PK studies (i.e. Brain, lung, soft tissue, and bone)
○ Single- and multiple-dose PK studies
○ Dose fractionation studies
○ Time course studies

Other Preclinical Services

Our scientists have skill sets covering a broad range of Research and Development, and we have also formed many strategic alliances along the Life Sciences Corridor. Our internal expertise and external collaborations allow us to offer a wide variety of additional services upon request.

○ in vivo model development
○ Maximum Tolerated Dose (MTD) studies
○ Histology services
○ Tissue harvests
○ Bioanalytical analyses

In partnership with the Southwest Michigan Innovation Center, TransPharm provides assay development or adopts existing methods to provide LC-MS/MS quantitative analysis of compounds in serum, plasma, and tissue. Combine our services to speed up your data delivery.