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Peritonitis

Peritonitis is defined as inflammation of the peritoneum, the transparent membrane which lines the abdominal cavity and covers the abdominal organs. Peritonitis can result from any perforation of the abdomen or as a complication of other medical conditions. Left untreated, it can lead to a severe, life-threatening infection throughout the body. We have an established a peritonitis model that is commonly used as the first step to evaluate therapeutic efficacy in vivo.

Procedure
We have established a peritonitis model in both mice and rats in which animals receive a single challenge with an infectious agent via intraperitoneal (IP) injection. Animals may be administered test article via oral gavage (PO) or subcutaneous (SC), intravenous (IV), or intraperitoneal (IP) injection. The route, duration, and frequency of dosing can be customized to meet client needs. Endpoints for this study include mortality tracking and CFU burden in harvested organs and/or blood. Pharmacokinetic profiling, blood chemistry, and histology are available upon request.

Pathogens
TransPharm has validated a peritonitis model using the following pathogens:

  • Acinetobacter baumannii
    • ATCC 17961
  • Candida albicans
    • ATCC SC5314
  • Coxsackievirus
    • ATCC VR-30
  • Enterococcus faecalis
    • 03A1065
  • Enterococcus faecium
    • 03B1022
  • Escherichia coli
    • Vogel
    • ATCC 25404
    • ATCC BAA-2469
  • Klebsiella pneumoniae
    • ATCC BAA-2146
  • Neiserria meningitidis
    • ATCC BAA-335
  • Pseudomonas aeruginosa
    • ATCC 15692
    • ATCC 27853
    • ATCC 33347
  • Staphylococcus aureus
    • ATCC 13709
    • ATCC 33592
    • ATCC BAA-1707 (USA400)
    • UC-76-rp
    • USA300
    • 01A1095
  • Staphylococcus epidermidis
    • ATCC 9491

Additional validations are available upon request.