Minimum Inhibitory Concentration (MIC) Testing

Minimum Inhibitory Concentration (MIC) Testing

A minimum inhibitory concentration (MIC) assay determines the lowest concentration of drug needed to kill a pathogen by measuring growth inhibition of the microbe. TransPharm Preclinical Solutions offers MIC assays using both agar and broth dilution methods. Our on-site library contains hundreds of validated pathogens, including many multidrug-resistant (MDR) strains, and additional strains can be obtained upon request. Contact us to learn more about in vitro efficacy testing of your test article or to request a free, no-obligation quote.

Procedure
Serial dilutions of test article are added to agar or media inoculated with a standard concentration of a susceptible pathogen. A positive and negative control are included to demonstrate bacterial growth and media sterility, respectively. The cultures are incubated overnight. The MIC value is the lowest concentration of test article that does not show bacterial or fungal growth.

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