Blog

Blog

Gnotobiotic and Germ-Free Animals

TransPharm Preclinical Solutions is a full-service contract research organization specializing exclusively in microbiology and infectious disease research. We regularly perform efficacy testing of novel antimicrobial therapeutics in mice and rats. Some specialized studies require gnotobiotic, or germ-free, animals. While the average mouse or rat is home to trillions of commensal bacteria and fungi in places like the skin, nose, and gut, gnotobiotic animals are devoid of these microbes.

read more

Drug Take Back Day

Prescription and over-the-counter medications are necessary for treating disease and saving lives, but they can also cause serious public health and safety concerns.

National Drug Take Back Day provides an opportunity for you to make a difference by preventing accidental poisoning, drug abuse and addiction, and overdose deaths. By cleaning out your medicine cabinet of expired or unwanted pills, you can help keep drugs out of the wrong hands (or paws).

read more

Imaging Infections

TransPharm Preclinical Solutions performs efficacy testing of novel therapeutics against a wide variety of infections in mice and rats. Historically, analysis of microbial burden has been performed using tissue harvests and cultures, a multi-step method...

read more

Common Antibacterial Agent Contributes to Antibiotic Resistance

Stores are stocked with items promising to kill bacteria, and many consumers purchase those products in an attempt to protect themselves from infection. However, it turns out that could be doing more harm than good. A common ingredient in products you use every day could be driving antibiotic resistance. Triclosan, a chemical found in everything from toothpaste and cosmetics to toys and credit cards, has been added for decades to keep these products free of microbes. Previously, contact with triclosan was considered safe for humans, but recent data shows otherwise.

read more

Jackson is our Valentine

February 14th is all about love and we sure do love our town of Jackson, Michigan. In fact, on this day 126 years ago, Jackson officially became a city. And did you know that the rose is the official flower of Jackson, which is also known as the Rose City? How fitting! So happy Valentine’s Day and happy birthday, Jackson. TransPharm Preclinical Solutions is proud to call you home.

read more

IACUC Approves Intratracheal Administration

TransPharm’s Institutional Animal Care and Use Committee (IACUC) recently approved intratracheal (IT) administration as a new route of inoculating and dosing mice. Intratracheal administration delivers infections and compounds directly to the lungs, while intranasal (IN) administration serves as an indirect delivery method.

read more

A “Two-Hit” Model of Sepsis

TransPharm recently validated a “two-hit” model of sepsis in which mice undergo cecal ligation and puncture (CLP) followed by intranasal instillation with bacteria to initiate a pulmonary infection.

read more

Cease and Persist?

After a bacterial infection is established, a small percentage of the bacteria slow their metabolism in response to environmental stressors. This semi-dormant state affords increased tolerance to antibiotics, especially aminoglycosides, lending these bacteria the name persisters. Over time, and often upon completion of a course of antibiotics, the persisters reactivate, leading to recurrent, chronic, and increasingly aggressive infections. Persistence is one of many mechanisms contributing to increasing rates of antibiotic resistance in modern healthcare.

read more

Biofilms: Skimming the Surface

A biofilm is a thin layer of microorganisms that have adhered to a surface and formed a complex, multicellular, three-dimensional structure. The National Institute of Health (NIH) reports that biofilms account for 80% of microbial infections in humans and have the ability to affect every organ in the body. Biofilms can form on living tissues, but also on artificial surfaces like catheters, prosthetics, pacemakers, and other medical devices. Pathogenic bacteria known to form biofilms include Escherichia coli, Staphylococcus aureus, and Salmonella species.

read more

Trick and Treat Bacteria

What do the ancient Greeks and a group of modern-day researchers have in common? Scientists at the University of Washington School of Medicine are using a “Trojan Horse” strategy to trick and treat (Happy Halloween!) antibiotic-resistant bacteria. Pseudomonas aeruginosa, a superbug that can cause serious wound and lung infections, relies on the uptake of iron to survive and spread. Microbiologists discovered that gallium, a metal similar to iron, tricks the bacteria by mimicking the essential nutrient. However, once inside, gallium fails to nourish the bacteria in the way iron does – and it actually harms them.

read more

Contact Us

15 + 15 =

science exchange logo

scientist.com logo

Jackson Certified
Brooklyn-Irish Hills Chamber of Commerce logo