Imaging Infections

Imaging Infections

  1. Home
  2. Blog
  3. Imaging Infections

TransPharm Preclinical Solutions performs efficacy testing of novel therapeutics against a wide variety of infections in mice and rats. Historically, analysis of microbial burden has been performed using tissue harvests and cultures, a multi-step method that can take up to 72 hours and often requires euthanizing research animals. However, new technology has been developed which allows for real-time, in vivo visualization of bacteria using a non-invasive 2D imaging system called the IVIS Lumina S5.

When exposed to light emitted by the device, the intensity and location of infections can be observed on a display screen. The device also allows for imaging of tagged therapeutics after dosing, giving insight into drug distribution and pharmacokinetics. This state-of-the-art method provides immediate results and can image up to 5 mice or 3 rats simultaneously. Because the animals are anesthetized and not sacrificed, subsequent imaging gives further insight into infection progression and/or therapeutic efficacy over time. Ultimately, the high-throughput IVIS S5 delivers speeds up the time required to get new infectious disease drugs to market where they can save patient lives.

CONTACT US






    Please prove you are human by selecting the tree.

    science exchange logo

    scientist.com logo

    Jackson Certified
    Brooklyn-Irish Hills Chamber of Commerce logo