E. coli in Retail Poultry May Cause UTIs

Foodborne bacteria are a common cause of gastrointestinal infection, but a recent study found that a strain of E. coli in retail chicken and turkey may be transmitted to humans and cause other infections. Researchers conducted a one-year study of urine and blood...

Synergistic Combination Therapy Against Resistant Pathogens

Due to increasing rates of antimicrobial resistance, scientists are researching the potential of combination therapy (two or more drugs used together) to restore activity against resistant pathogens. In a recent study, investigators screened 19 antibiotics with...

Trained Dog Can Detect C. difficile

The nose knows! A dog in British Columbia, Canada has been trained to detect Clostridium difficile. C. difficile is a Gram-positive, anaerobic bacterium found in the gastrointestinal tract. Most people with C. difficile colonization are asymptomatic, but antibiotic...

NDM-1 and Drug Resistance

NDM-1 is a gene that codes for New Delhi metallo-beta-lactamase 1, an enzyme that provides resistance to multiple classes of antibiotics, including carbapenems, cephalosporins, and penicillins. Pathogens carrying this gene typically carry other resistance genes as...

Preclinical Research in Drug Development

Preclinical studies provide data about drug safety and efficacy in animals to determine if the drug should proceed to clinical testing in humans. Three important factors to consider when conducting preclinical research are pharmacodynamics, pharmacokinetics, and...

Economic Forecast for Preclinical CROs

Research and development (R&D), as well as manufacturing, are often outsourced from big pharma to smaller contract research organizations (CRO) with more resources and specialized expertise. As the global pharmaceutical market grows, so too does the need for...