A “Two-Hit” Model of Sepsis

TransPharm recently validated a “two-hit” model of sepsis in which mice undergo cecal ligation and puncture (CLP) followed by intranasal instillation with bacteria to initiate a pulmonary infection. Although sepsis is a major cause of mortality in hospital...

Cease and Persist?

After a bacterial infection is established, a small percentage of the bacteria slow their metabolism in response to environmental stressors. This semi-dormant state affords increased tolerance to antibiotics, especially aminoglycosides, lending these bacteria the name...

Biofilms: Skimming the Surface

There are two basic forms of microbes: free-floating and anchored. While free-floating microbes are better understood, 90% of all microorganisms are anchored. Anchored microbes have the ability to form biofilms. A biofilm is a thin layer of microorganisms that have...

Trick and Treat Bacteria

What do the ancient Greeks and a group of modern-day researchers have in common? Scientists at the University of Washington School of Medicine are using a “Trojan Horse” strategy to trick and treat (Happy Halloween!) antibiotic-resistant bacteria. Pseudomonas...

E. coli in Retail Poultry May Cause UTIs

Foodborne bacteria are a common cause of gastrointestinal infection, but a recent study found that a strain of E. coli in retail chicken and turkey may be transmitted to humans and cause other infections. Researchers conducted a one-year study of urine and blood...

Synergistic Combination Therapy Against Resistant Pathogens

Due to increasing rates of antimicrobial resistance, scientists are researching the potential of combination therapy (two or more drugs used together) to restore activity against resistant pathogens. In a recent study, investigators screened 19 antibiotics with...