NDM-1 and Drug Resistance

NDM-1 is a gene that codes for New Delhi metallo-beta-lactamase 1, an enzyme that provides resistance to multiple classes of antibiotics, including carbapenems, cephalosporins, and penicillins. Pathogens carrying this gene typically carry other resistance genes as...

Preclinical Research in Drug Development

Preclinical studies provide data about drug safety and efficacy in animals to determine if the drug should proceed to clinical testing in humans. Three important factors to consider when conducting preclinical research are pharmacodynamics, pharmacokinetics, and...

Economic Forecast for Preclinical CROs

Research and development (R&D), as well as manufacturing, are often outsourced from big pharma to smaller contract research organizations (CRO) with more resources and specialized expertise. As the global pharmaceutical market grows, so too does the need for...

These Pathogens Can ESKAPE Most Antibiotics

Antimicrobial resistance poses an ever-increasing healthcare threat, with pathogens evolving resistance faster than novel therapies are being developed. ESKAPE pathogens are just six of the many bacteria which have acquired the ability to escape the actions of current...

Fecal Transplants Treat C. difficile Infections

Clostridium difficile, more commonly known as C. diff, is a bacterium that causes gastrointestinal infections and severe diarrhea. C. difficile infection (CDI) is the most common healthcare-associated infection in the United States, with nearly half a million cases...

Phage Therapy Against Super Bugs

Superbugs, or multi-drug resistant (MDR) bacteria, are bacteria that cannot be killed using two or more antibiotics. Any species of bacteria can become a superbug, and misusing antibiotics is the leading factor contributing to this growing problem. There are...